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2012年4月23日 (月)

業績 - 教授 湯澤由紀夫 (2012/04/23)

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Name:Yukio Yuzawa M.D., Ph.D.

INVITED GUEST SPEAKER AT INTERNATIONAL SCIENTIFIC MEETINGS

Invited Lecture, Lupus Nephritis Asian Forum, Beijing, China
“Country Specific Issues: Japan” March 24, 2012
Invited Speaker, the Sixth Congress of Nephrology in Internet, CIN2011,
“Urinary biomarkers in acute kidney injury.” September, 2011
Invited Lecture, 7th International Congress on Uremia Research and Toxicity, Nagoya, Japan
“Cross-talk between kidney and lung in critical care nephrology” May 12-14, 2011
Invited Lecture, World Congress of Nephrology 2011, Vancouver, Canada  April 11, 2011
Simposium “Theme 4 Acute Kidney Injury
“AKI and Midkine”
International Synpojium, The 55th annual meeting of Japanese Society of Dialysis Tharapy, Kobe, Japan
   Session 8-3: [Efficacy of blood purification on AKI; Early Detection and Intervention]   June 18. 2010
“Clinical Implication of Biomarkers for Acute Kidney Injury”
Invited Lecture, The 12th Asian Pacific Congress of Nephrology, Seoul, Korea  June 5, 2010
   Simposium 03 Acute Kidney Injury; Clinical
“Biomarkers of AKI”
Invited Lecture, ISN-Nexus, Kyoto, Japan
Meet the Professor: 19. Aspects of vascular changes in renal biopsy April 17, 2010
Invited Lecture, 4th  CKD Forum in Nagoya, Nagoya, Japan Feb. 20 , 2010
   “The growth factor midkine regulates the rennin-angiotensin system in CKD”
Invited Lecture, 27th Annual meeting of the International Society of Blood Purification , Stockholm, Sweden
    Symposium “Infection and immune dysfunction in dialysis patients”   September 19, 2009
Invited Lecture, World Congress of Nephrology 2009, Milano, Italy May 23 , 2009 
    Symposium "From pathophysiology to biomarkers"
          "Biomarkers as windows into the pathogenesis of AKI: Midkine"
Invited Lecture, 3rd  CKD Forum in Nagoya, Nagoya, Japan  Feb. 15, 2009
   “Characteristics and causes of immune dysfunction related to uremia and dialysis”
Invited Lecture, 8th Symposium of Kidney Institute, Keimyung University,  Deagu, South Korea     Oct. 28, 2008
“ Glomerulonephritis Treatment Update”
  Session 2    IgA Nephropathy: treatment update
  Session 3    Tacrolimus in glomerular disease
Invited Lecture, 12th Congress of the International Society for Peritoneal Dialysis, Istanbul , Turkey June 22, 2008
“The role Toll-like receptors for hypercytokinemia in uremic patients including PD patients “
Invited Lecture, 3rd Asian Chapter Meeting of International Society for Peritoneal Dialysis
(ACM-ISPD 2007), Hiroshima, Japan                                                       Nov. 24, 2007
    “Characteristics and Causes of Immune Dysfunction in Uremia”
Invited Lecture, International Symposium of Systemic Vasculitis,  Tokyo,  Japan     2005

Patent Application:
1.URINARY MIDKINE AS A BIOMARKER FOR ACUTE KIDNEY INJURY: PCT/JP2009/000863
2.THERAPEUTIC METHOD TARGETING MIDKINE: US12/554,560

Publication:
Over 100 peer reviewed papers in the field of experimental nephrology and clinical nephrology

1.Andres G, Yuzawa Y, Cavalot F.: Recent progress in renal immunopathology, Human Pathology, 19, 1132-1143, 1988)
2.Fukatsu A, Yuzawa Y, Niesen N, Matsuo S, Caldwell PRB, Brentjens JR, Andres G.: Local formation of immune deposits in rabbit renal proximal tubules, Kidney International, 34, 611-619, (1988)
3.Fukatsu A, Yuzawa Y, Brentjens J, Andres G.: Renal immune deposits induced by antibodies reactive with cell-surface antigens in laboratory animals and in man, American Journal of Nephrology, 9 (sup 1), 27-29, 1989
4.Matsuo S, Yoshida F, Yuzawa Y, Hara S, Fukatsu A, Watanabe Y, Sakamoto N.:Experimental glomerulonephritis induced in rats by a lectin and its antibodies, Kidney International, 36, 1011-1021, 1989
5.Yoshida F, Matsuo S, Hiramatsu T, Okura T, Yuzawa Y, Watanabe Y, Sakamoto N.: Glomerular injury induced by antibodies against heparan sulfate proteoglycan (HSPG) derived from PYS2 cells, Japanese Journal of Nephrology, 31, 15-23,1989
6.Fukatsu A, Yuzawa Y, Olson L, Miller J, Milgrom M, Zamlauski-Tucker MJ, Van Liew JB, Campagnari A, Niesen N, Patel J, Doi T, Striker L, Striker G, Milgrom F, Brentjens J, Andres.: Interaction of antibodies with human glomelular epithelial cells, Laboratory Investigation, 61, 389-403, 1989
7.Matsukawa W, Hara S, Yoshida F, Suzuki N, Fukatsu A, Yuzawa Y, Sakamoto N, Matsuo S.: Effects of a new immunosuppressive agent, FK506, in rats with active Heymann nephritis, Journal of Laboratory and Clinical Medicine, 119(2), 116-123, 1992
8.Fukatsu A, Ito Y, Yuzawa Y, Yoshida F, Kato M, Miyakawa K, Matsuo S.:A case of POEMS syndrome showing elevated serum interleukin 6 and abnormal expression of interleukin 6 in the kidney, Nephron, 47-51, 1992
9.Fukatsu A, Matsuo S, Yuzawa Y, Miyai H, Futenma A, Kato K.: Expression of interleukin-6 and major histocompatibility complex molecules in tubular epithelial cells of diseased human kidneys, Laboratory Investigation, 69, 58-67, 1993
10.Watanabe Y, Mizumoto D, Yuzawa Y, Itoh Y, Tamai H, Kumon S, Yamazaki C, Sekiyama S, Yoshida F, Fukatsu A, Suzuki N, Sakamoto N, Matsuo.: Long-term follow-up study of 268 diabetic patients undergoing hemodialysis with special attention to visual acuity and heterogeneity, Nephrology Dialysis Transplantation, 8, 725-738, 1993
11.Yuzawa Y, Brentjens JR, Brett J, Caldwell PRB, Esposito C, Fukatsu A, Goldman G, Stern D, Andres G.: Antibody-mediated redistribution and shedding of endothelial antigens in the rabbit, Journal of Immunology, 150, 5633-5646, 1993
12.Mizutani M, Yuzawa Y, Maruyama I, Sakamoto N, Matsuo. :Glomerular localization of thrombomodulin in human glomerulonephritis,  Laboratory Investigation, 69, 193-202, 1993
13.Sekiyama S, Yoshida F, Yuzawa Y, Fukatsu A, Suzuki N, Sakamoto N, Matsuo.: Mesangial proliferative glomerulonephritis induced in rats by a lectin and its antibodies, Journal of Laboratory and Clinical Medicine, 121, 71-82, 1993
14.Yoshida F, Yuzawa Y, Shigematsu H, Ito A, Yamazaki C, Yoshioka K, Ooshima A, Matsuo S.: Nephrotic syndrome with massive accumulation of type I and type III collagen in the glomeruli, Internal Medicine, 32, 171-176, 1993
15.Yuzawa Y, Aoi N, Fukatsu A, Ichida S, Yoshida F, Akatsuka Y, Minami S, Kodera Y, Matsuo S.: Acute renal failure and degenerative tubular lesions associated with in situ formation of adenovirus immune complexes in a patient with allogeneic bone marrow transplantation, Transplantation, 55, 67-72, 1993
16.Ichida S, Yuzawa Y, Okada H, Yoshioka K, Matsuo.: Localization of complement regulatory proteins in the normal human kidney. Kidney International, 46, 89-96, 1994
17.Ito Y, Suzuki T, Mizuno M, Muto E, Ichida S, Hananouchi M, Yuzawa Y, Matsuo S.: A case of renal sarcoidosis showing central necrosis and abnormal expression of angiotensin converting enzyme in thegranuloma, Clinical Nephrology, 42, 331-336, 1994
18.Mizumoto D, Watanabe Y, Fukuzawa Y, Yuzawa Y, Yamazaki C.: Identification of risk factors on secondary hyperparathyroidism undergoing long-term haemodialysis with vitamin D3, Nephrology Dialysis Transplantation, 9: 1751-1758, 1994
19.Hatanaka Y, Yuzawa Y, Nishikawa K, Fukatsu A, Okada N, Okada H, Mizuno M, Matsuo S.: Role of a rat membrane inhibitor of complement in anti-basement membrane antibody-induced renal injury.  Kidney International, 48, 1728-1737, 1995
20.Nomura A, Nishikawa K, Yuzawa Y, Okada H, Morgan BP, Piddlesden SJ, Nadai M, Hasegawa T, Matsuo S.: Tubulointerstitial injury induced in rats by a monoclonal antibody which inhibits function of a membrane inhibitor of complement, Journal of Clinical Investigation, 96, 2348-2356, 1995
21.Yuzawa Y, Brett J, , Fukatsu A, Matsuo S, Caldwell PRB, Niesen N, Milgrom F, Godman G, Stern D, Andres G.: Interaction of antibody with Forssman antigen in Guinea pigs, American Journal of Pathology, 146, 1260-1272, 1995
22.Akahori T, Yuzawa Y, Nishikawa K, Tamatani T, Kannagi R, Miyasaka M, Okada H, Hotta N, Matsuo.: Selective expression of a novel complex sialyl LewisX epitope on vascular endothelium in a rat model of local skin inflammation. Journal of Immunology, 158, 5384-5392, 1997
23.Morita Y, Nomura A, Hotta N, Yuzawa Y, Nishikawa K, Shimizu F, Matsuo.: The role of complement in the development of tubulointerstitial injury of rats with mesangial proliferative glomerulonephritis, Journal of American Society of Nephrology, 8, 1363-1372, 1997
24.Matsuo S, Morita Y, Mizuno M, Nishikawa K, Yuzawa Y.: Proteinuria and damage to the tubular cells - is complement a culprit?  Nephrology Dialysis Transplantation, 13: 2723-2726, 1998
25.Matsuo S, Morita Y, Mizuno M, Nishikawa K, Yuzawa Y .: Complement-mediated renal injury: mechanisms and role of membrane inhibitors of complement, Clinical and Experimental Nephrology, 2: 276-281, 1998
26.Fan Q, Uchimura K, Yuzawa Y, Matsuo S, Matsuoka C, Kannagi R, Muramatsu H, Kadomatsu K, Muramatsu T.: Spacially and temporally regulated expression of N-acetylglucosamine-6-O- sulfotransferase during mouse embryogenesis, Glycobiology, 9, 947-955, 1999
27.Horiba M, Kadomatsu K, Nakamura E, Muramatsu H, Ikematsu S, Sakuma S, Hayashi K, Yuzawa Y, Matsuo S, Kuzuya M, Kaname T, Hirai M, Saito H, Muramatsu T.: Neointima formation in a model is suppressed in midkine-deficient mice, Journal of Clinical Investigation, 106: 489-495, 2000
28.Mizuno M, Nishikawa K, Yuzawa Y, Kanie T, Mori H, Araki Y, Hotta N, Matsuo S.: Acute renal failure induced by a Sea Anemone,  American Journal of Kidney Disease, 36, E10-13, 2000
29.Morita Y, Ikeguchi H, Nakamura J, Hotta N, Yuzawa Y, Matsuo S.: Complement activation products in the urine from proteinuric patients. Journal of American Society of Nephrology, 11, 700-707, 2000
30.Watanabe M, Morita Y, Mizuno M, Nishikawa K, Yuzawa Y, Hotta N, Morgan BP, Okada N, Okada N, Matsuo S.: CD59 protects kidneys from complement mediated injury in collaboration with Crry in rats, Kidney International, 58, 1569-1579, 2000
31.Matsuo S, Morita Y, Mizuno M, Nishikawa K, Yuzawa Y.: The role of complement in the progression of renal fibrosis: a clinical study, Nephrology Dialysis Transplantation, 15 (Sup6): 53-54, 2000
32.Kondo C, Mizuno M, Nishikawa K, Yuzawa Y, Hotta N, Matsuo S.: The role of C5a in the development of thrombotic glomerulonephritis in rats, Clinical and Experimental Immunology, 124, 323-329, 2001
33.Ito I, Yuzawa Y, Mizuno M, Nishikawa K, Tashita A, Jomori T, Hotta N, Matsuo S.: The effects of a new synthetic selection blocker in an acute rat thrombotic glomerulonephritis, American Journal of Kidney Disease,  38: 265-273, 2001
34.Kasuga H, Ito Y, Sakamoto S, Kawachi H, Shimizu F, Yuzawa Y, Matsuo S.: Effects of anti-TGF- type II receptor antibody on experimental glomerulonephritis, Kidney International,62, 1745-1755, 2001
35.Sato W, Kadomatsu K, Yuzawa Y, Muramatsu H, Hotta N, Matsuo S, Muramatsu T.: Midkine is involved in neutrophil infiltration into the tubulointerstitium in ischemic renal injury, Journal of Immunology, 167, 3463-3469, 2001
36.Ikeguchi H, Maruyama S, Morita Y, Fujita Y, Kato T, Natori Y, Akatsu H, Cambell W, Okada N, Okada H, Yuzawa Y, Matsuo S .: Effects of human soluble thrombomodulin on experimental glomerulonephritis, Kidney International, 61: 490-501, 2002
37.Naruse T, Yuzawa Y, Akahori T, Mizuno M, Maruyama S, Kannagi R, Hotta N, Matsuo S.: P-selectin-dependent macrophage migration into the tubulointerstitium via vasa recta in rats with unilateral ureteral obstruction, Kidney International, 62: 94-105, 2002
38.Sato W, Yuzawa Y, Kadomatsu K, Tayasu T, Muramatsu S, Muramatsu T, Matsuo S.: Midkine expression in the course of nephrogenesis and its role in ischemic reperfusion injury, Nephrology Dialysis Transplantation, 17, 52-54, 2002
39.Manchang L, Takahashi H, Morita Y, Maruyama S, Mizuno M, Yuzawa Y, Watanabe M, Toriyama T, Kawahara H, Matsuo S.: Non-dipping is a potent predictor of cardiovascular mortality and is associated with autonomic dysfunction in haemodialysis patients, Nephrology Dialysis Transplantation, 18, 563-569, 2003
40.Shimizu H, Maruyama S, Yuzawa Y, Kato T, Miki Y, Suzuki S, Sato W, Morita Y, Maruyama H, Egashira K, Matsuo S .: Anti-monocyte chemoattractant protein-1 gene therapy attenuates renal injury induced by protein-overload proteinuria,  Journal of American Society of Nephrology, 14, 1496-1505, 2003
41.Matsuo S, Morita Y, Maruyama S, Manchang L, Yuzawa Y,: Proteinuria and tubulointerstitial injury: The causative factors for the progression of renal diseases, Contribution of Nephrology, 139, 20-31, 2003
42.Manchang L, Maruyama S, Mizuno M, Morita Y, Hanaki S, Yuzawa Y, Matsuo S.: The nephrotoxicity of Aristorochia manshuriensis in rats is attributeable to its Aristrochic acids, Clinical and Experimental Nephrology, 7, 86-94,2003
43.Matsushita T, Hayashi H, Kunishima S, Hayashi M, Ikejiri M, Takeshita K, Yuzawa Y, Adachi T, Hirashima K, Sone M, Yamamoto K, Takagi A,Katsumi A, Kawai K, Nezu T, Takahashi T, Nakashima T, Naoe T,
44.Kojima T, Saito H.: Targeted disruption of mouse ortholog of the human MYH9 responsible for macrothrombocytopenia with different organ involvement: hematological, nephrological, and otological studies of heterozygousKO mice, Biochemical and Biophysical Research Communications, 32, 1163-1171, 2004
45.Sakakima H, Yoshida Y, Kadomatsu K, Yuzawa Y, Matsuo S, MuramatsuT.: Midkine expression in rat spinal motor neurons following sciatic nerveinjury, Brain Research Developmental Brain Research, 153(2), 251-260, 2004
46.Takei Y, Kadomatsu K, Yuzawa Y, Matsuo S, and Muramastu T.: A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics, Cancer Research, 64, 3365-3370, 2004
47.Miki Y, Maruyama S, Liu DG, Kobayashi T, Sato F, Shimizu H, Kato S,Sato W, Morita Y, Yuzawa Y, Muramatsu T, Matsuo S.: In vivo gene transfer of endo--galactosidase C removes Gal antigen erythrocytes and endothelial cells of the organs, Xenotransplantation, 11, 444-451, 2004
48.Kato S, Yuzawa Y, Tsuboi N, Maruyama S, Morita Y, Matsuguchi T, Matsuo S.: Endotoxin induced chemokine expression in murine peritoneal mesothelial cells: The role of Toll-like receptor 4,  Journal of American Society of Nephrology, 15, 1289-1299, 2004
49.Kawai H, Sato W, Yuzawa Y, Kosugi T, Matsuo S, Takei Y, KadomatsuK, Muramatsu T.: Lack of the growth factor midkine enhances survival against cisplatin-induced renal damage, American Journal of Pathology, 165, 1603-1612, 2004
50.Miyazaki M, Yuzawa Y.: The role of peritoneal fibrosis in encapsulating peritoneal sclerosis, Peritoneal Dialysis Internatinal, Sup 4, s48-56, 2005
51.Sato W, Takei Y, Yuzawa Y, Matsuo S, Kadomatsu K, Muramatsu T.: Midkine antisense oligodeoxyribonucleotide inhibits renal damage induced by ischemic reperfusion, Kidney International, 67(4), 1330-1339, 2005
52.Suzuki S, Maruyama S, Sato W, Morita Y, Sato F, Miki Y, Kato S, Katsuno M, Sobue G, Yuzawa Y, Matsuo S.: Geranylgeranylacetone ameliorates ischemic acute renal failure via induction of Hsp70, Kidney International, 67(6), 2210-20, 2005
53.Naruse K, Hamada Y, Nakashima E, Kato K, Mizubayashi R, Kamiya H, Yuzawa Y, Matsuo S, Murohara T, Matsubara T, Oiso Y, Nakamura J.: Therapeutic neovascularization using cord blood-derived endothelial progenitor cells for diabetic neuropathy, Diabetes, 54, 1823-8, 2005
54.Ichida S, Okada K, Itoh M, Okada R, Katoh N, Kasai M, Yuzawa Y.:Bone marrow transplant nephropathy successfully treated with angiotensin-converting enzyme inhibitor, Clinical and Experimental Nephrology, 10, 78-81, 2006
55.Kosugi T, Yuzawa Y, Sato W, Kawai H, Matsuo S, Takei Y, MuramatsuT, Kadomatsu K.: Growth factor midkine is involved in the pathogenesis of diabetic nephropathy, American Journal of Pathology, 168, 9-19, 2006 
56.Yasuda Y, Kasuga H, Aoyama T, Takahashi H, Toriyama T, Kawade Y, Iwashima S, Yamada S, Kawahara H, Maruyama S, Yuzawa Y, Ishii H, Murohara T, Matsuo S.: Comparison of percutaneous coronary interventionwith medication in the treatment of coronary artery disease in hemodialysis patients,  Journal of American Society of Nephrology, 17(8), 2322-2332, 2006
57.Nakagawa T, Sato W, Glushakova O, Heinig M, Clarke T, Campbell-Thompson M, Yuzawa Y., Atkinson MA, Johnson RJ, Croker B.: Diabeticendothelial nitric oxide synthase knockout mice develop advanced diabeticnephropathy, Journal of American Society of Nephrology, 18(2), 539-550,2007
58.Inaguma D, Tatematsu M, Shinjo H, Suzuki S, Mishima T, Inaba S, Kurata K, Yuzawa Y., Matsuo S.: Relationship between renal function at the time of percutaneous coronary intervention and prognosis in ischemic heart disease patients, Clinical and Experimental Nephrology, 11(1), 56-60, 2007
59.Kosugi T, Yuzawa Y.,Sato W, Arata-Kawai H, Suzuki N, Kato N, MatsuoS, Kadomatsu K.: Midkine is involved in tubulointerstitial inflammation associated with diabetic nephropathy, Laboratory Investigation, 87(9), 903-913. 2007
60.Ozaki T, Anas C, Maruyama S, Yamamoto T, Yasuda K, Morita Y, Ito Y, Gotoh M, Yuzawa Y., Matsuo S.: Intrarenal administration of recombinant human soluble thrombomodulin ameliorates ischaemic acute renal failure,  Nephrology Dialysis Transplantation, 23(1), 110-119, 2008
61.Ishimoto T, Takei Y, Yuzawa Y., Hanai K, Nagahara S, Tarumi Y, Matsuo S, Kadomatsu K.: Downregulation of monocyte chemoattractant protein-1 involving short interfering RNA attenuates hapten-induced contact hypersensitivity, Molecular Therapy, 16(2), 387-95, 2008
62.Aoyama T, Ishii H, Toriyama T, Takahashi H, Kasuga H, Murakami R, Amano T, Uetani T, Yasuda Y, Yuzawa Y., Maruyama S, Matsuo S, Matsubara T, Murohara T.: Sirolimus-eluting stents vs bare metal stents for coronary intervention in Japanese patients with renal failure on hemodialysis, Circulation Journal, 72(1):56-60, 2008
63.Takei Y, Nemoto T, Mu P, Fujishima T, Ishimoto T, Hayakawa Y, Yuzawa Y., Matsuo S, Muramatsu T, Kadomatsu K.: In vivo silencing ofa molecular target by short interfering RNA electroporation: tumor vascularization correlates to delivery efficiency, Molecular Cancer Therapeutics, 7(1), 211-221, 2008
64.Sato F, Maruyama S, Hayashi H, Sakamoto I, Yamada S, Uchimura I, Morita Y, Ito Y, Yuzawa Y., Maruyama I, Matsuo S.: High mobility group box chromosomal protein 1 in patients with renal diseases, Nephron Clinical Practis, 108(3), c194-201, 2008
65.Ishii H, Kumada Y, Toriyama T, Aoyama T, Takahashi H, Yamada S, Yasuda Y, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T.: Cilostazol improves long-term patency after percutaneous transluminal angioplasty in hemodialysis patients with peripheral artery disease, Clinical Journal of American Society of Nephrology, 3(4), 1034-40, 2008
66.Nishimura H,Ito Y, Mizuno M, Tanaka A, Morita Y, Maruyama S, Yuzawa Y, Matsuo S.: Mineralocorticoid receptor blockade ameliorates peritoneal fibrosis in new rat peritonitis model, American Journal of Physiology Renal Physiology, 294(5), F1084-93, 2008
67.Yaomura T, Tsuboi N, Urahama Y, Hobo A, Sugimoto K, Miyoshi J, Matsuguchi T, Kannagi R, Matsuo S, Yuzawa Y.: Serine/threonine kinase,Cot/Tpl2, regulates renal cell apoptosis in ischaemia/reperfusion injury. Nephrology, 13, 397-404, 2008
68.Yuzawa Y, Niki I, Kosugi T, Maruyama S, Yoshida F, Takeda M, Tagawa M, Kaneko Y, Kimura T, Kato N, Yamamoto J, Sato W, Nakagawa T and Matsuo S.: Overexpression of calmodulin in pancreatic beta cells induces diabetic nephropathy. Journal of American Society of Nephrology, 19(9), 1701-11, 2008
69.Kumada Y, Aoyama T, Ishii H,Tanaka M, Kawamura Y, Takahashi H, Toriyama T, Aoyama T, Yuzawa Y, Maruyama S, Matsuo S and Murohara T.: Long-term outcome of percutaneous transluminal angioplasty in chronic haemodialysis patients with peripheral arterial disease, Nephrology Dialysis Transplantation, 23(12), 3996-4001, 2008
70.Sato W, Kosugi T, Zhang L, Roncal CA, Heinig M, Campbell-Thompson M, Yuzawa Y, Atkinson MA, Grant MB, Croker BP and Nakagaw /T.: The pivotal role of VEGF on glomerular macrophage infiltration in advanced diabetic nephropathy, Laboratory Investigation, 88(9), 949-61, 2008
71.Kato S, Chmielewski M, Honda H, Pecoits-Hilho R, Matsuo S, Yuzawa Y, Tranaeus A, Stenvinkel O, Lindholm.: Aspects of immune dysfunction inend-stage renal disease, Clinical Journal of American Society of Nephrology, 3(5), 1526-33, 2008
72.Anas CM, Hattori R, Morita Y, Matsukawa Y, Komatsu, T, Yoshino Y, Maruyama S, Yuzawa Y., Matsuo S, Gotoh M.: Efficiency of laparoscopic-assisted renal biopsy, Clinical Nephrology, 70(3), 203-209, 2008
73.Hauser AB, Stinghen AE, Kato S, Bucharles S, Aita C, Yuzawa Y and Pecoits-Filho R.: Characteristics and causes of immune dysfunction relatedto uremia and dialysis, Peritoneal Dialysis International, 28 Sup 3, S183-187, 2008
74.Urahama Y, Ohsaki Y, Fujita Y, Maruyama S, Yuzawa Y, Matsuo S, Fujimoto T.: Lipid droplet-associated proteins protect renal tubular cells from fatty acid-induced apoptosis, American Journal of Pathology, 173(5), 1286-1294, 2008
75.Maruyama S, Taguchi A, Iwashima S, Ozaki T, Yasuda K, Kikuchi-TauraA, Soma T, Ishii H, Murohara T, Takahashi H, Kasuga H, Kumada Y,   Toriyama T, Ito Y, Kawahara H, Yuzawa Y and Matsuo S.: Low circulating CD34+ cell count is associated with poor prognosis in chronichemodialysis patients, Kidney International, 74(12), 1603-1609, 2008
76.Iwashima S, Ozaki T, Maruyama S, Saka Y, Kobori M, Omae K, Yamaguchi H, Niimi T, Toriyama K, Kamei Y, Torii S, Murohara T, Yuzawa Y, Kitagawa Y, and Matsuo S.: Novel Culture System of Mesenchymal Stromal Cells from Human Subcutaneous Adipose Tissue, Stem Cells and Development, 18 (4), 533-543, 2009
77.Sugiura F, Kojima T, Oguchi T, Urata S, Yuzawa Y, Sakakibara A, Hayashi H, Norihiro N, Ishiguro N.: A case of peripheral neuropathy andskin ulcer in a patient with rheumatoid arthritis after a single infusion of tocilizumab, Modern Rheumatology, 19 (2), 199-203, 2009
78.Sakamoto I, Ito Y, Mizuno M, Suzuki Y, Sawai A, Tanaka A, MaruyamaS, Takei Y, Yuzawa Y, Matsuo S.: Lymphatic vessels develop during tubulointerstitial fibrosis, Kidney International, 75(8), 828-838, 2009
79.Kato N, Yuzawa Y, Kosugi T, Hobo A, Sato W, Miwa Y, Sakamoto K, Matsuo S, Kadomatsu K.: The E-selectin ligand basigin/CD147 is responsible for neutrophil recruitment in renal ischemia/reperfusion., Journal of American Society of Nephrology, 20(7), 1565-1576, 2009
80.Kosugi T, Heinig M, Nakayama T, Connor T, Yuzawa Y, Li Q, Hauswirth WW, Grant MB, Croker BP, Campbell-Thompson M, Zhang L, Atkinson MA, Segal MS, Nakagawa T.: Lowering blood pressure blocks mesangiolysis and mesangial nodules, but not tubulointerstitial injury, in diabetic eNOS knockout mice, American Journal of Pathology, 174(4), 1221-1229, 2009
81.Ishikawa H, Ito S, Nishio N, Yuzawa Y, Matsuo S, Isobe K.: Injection of bleomycin in newborn mice induces autoimmune sialitis that is transferred by CD4 T cells, Immunological Cell Biology, 87(4), 351-358, 2009
82.Ishii H, Kumada Y, Toriyama T, Aoyama T, Takahashi H, Amano T, Yasuda Y, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T.: Aortic valvular calcification predicts restenosis after implantation of drug-eluting stents in patients on chronic haemodialysis, Nephrology Dialysis Transplantation, 24(5), 1562-1567, 2009
83.Hobo A, Yuzawa Y, Kosugi T, Kato N, Asai N, Sato W, Maruyama S, Ito Y, Kobori H, Ikematsu S, Nishiyama A, Matsuo S, Kadomatsu K: The growth factor midkine regulates the renin-angiotensin system in mice., Journal of Clinical Investigation, 119 (6), 1616-1625, 2009
84.Kosugi T, Nakayama T, Heinig M, Zhang L, Yuzawa Y, Sanchez-Lozada LG, Roncal C, Johnson RJ, Nakagawa T.: Effect of lowering uric acid onrenal disease in the Type 2 diabetic db/db mice, American Journal of Physiology Renal Physiology, 297, F481-488, 2009
85.Mizuno M, Ito Y, Hepburn N, Mizuno T, Noda Y, Yuzawa Y, Harris CL, Morgan BP, Matsuo S.: Zymosan, but not lipopolysaccharide, triggers severe and progressive peritoneal injury accompanied by complement activation in a rat peritonitis model, Journal of Immunology, 183, 1403-1412, 2009
86.Kurata K, Maruyama S, Kato S, Sato W, Yamamoto J, Ozaki T, Nitta A,Nabeshima T, Morita Y, Mizuno M, Ito Y, Yuzawa Y, Matsuo S: Tissue-type plasminogen activator deficiency 1 attenuates peritoneal fibrosis in mice., American Journal of Physiology Renal Physiology, 297(6), F1510-1517, 2009
87.R.Okada, Y.Yuzawa, T.Kawamura, N.Hamajima, Y.Watanabe, S.Matsuo, for the Fever of Unknown Origin in Hemodialysis Patients (FUO-HD) Study Group: Incidence of fever of unknown origin and subsequent antitubercular medications in hemodialysis patients: a two-year prospective study., Ren Fail. 31(10):863-8. 2009
88.Ishii H, Toriyama T, Aoyama T, Takahashi H, Amano T, Hayashi M, Tanaka M, Kawamura Y, Yasuda Y, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T. Prognostic values of C-reactive protein levels on clinical outcome after implantation of sirolimus-eluting stents in patients on hemodialysis. Circ Cardiovasc Interv. 2(6):513-8. 2009
89.Yuzawa Y, Sato W, Masuda T, Hamada Y, Tatematsu M, Yasuda Y, Ozaki T, Ito I, Mizuno M, Maruyama S, Ito Y, Matsuo S.: Acute kidney injury presenting feature of leukemic infiltration during a therapy of chronic myelogenous leukemia, Internal Medicine, 49(12):1139-42 . 2010
90.Mizutani M, Ito Y, Mizuno M, Nishimura H, Suzuki Y, Hattori R, Matsukawa Y, Imai M, Oliver N, Goldschmeding R, Aten J, Krediet RT, Yuzawa Y, Matsuo S. Connective tissue growth factor (CTGF/CCN2) is increased in peritoneal dialysis patients with high peritoneal solute transport rate. Am J Physiol Renal Physiol. 298 (3): F721-33 . 2010
91.Nagaya H, Inaguma D, Kitagawa A, Murata M, Kamimura Y, Hamaguchi K, Tatematsu M, Suzuki S, Kurata K, Yuzawa Y, Matsuo S. Intravenously administered darbepoetin alfa once a week could maintain hemoglobin level more efficiently than once every 2 weeks in patients on hemodialysis. Clin Exp Nephrol. 14(2):158-63. 2010
92.Ishii H, Kumada Y, Toriyama T, Aoyama T, Takahashi H, Tanaka M, Kamoi D, Kawamura Y, Yamada S, Hayashi M, Yasuda Y, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T. : Effects of oral cilostazol 100 mg BID on long-term patency after percutaneous transluminal angioplasty in patients with femoropopliteal disease undergoing hemodialysis: A retrospective chart review in Japanese patients. Clin Ther ;32(1):24-33, 2010
93.Yamada S, Ishii H, Takahashi H, Aoyama T, Morita Y, Kasuga H, Kimura K, Ito Y, Takahashi R, Toriyama T, Yasuda Y, Hayashi M, Kamiya H, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T. Prognostic Value of Reduced Left Ventricular Ejection Fraction at Start of Hemodialysis Therapy on Cardiovascular and All-Cause Mortality in End-Stage Renal Disease Patients. Clin J Am Soc Nephrol. 5(10):1793-8, 2010
94.Ito Y, Goldschmeding R, Kasuga H, Claessen N, Nakayama M, Yuzawa Y, Sawai A, Matsuo S, Weening JJ, Aten J. Expression patterns of connective tissue growth factor and of TGF{beta} isoforms during glomerular injury recapitulate glomerulogenesis. Am J Physiol Renal Physiol. 299(3): F545–F558, 2010
95.Sugiura S, Inaguma D, Kitagawa A, Murata M, Kamimura Y, Sendo S, Hamaguchi K, Nagaya H, Tatematsu M, Kurata K, Yuzawa Y, Matsuo S., Administration of alfacalcidol for patients with predialysis chronic kidney disease may reduce cardiovascular disease events. Clin Exp Nephrol. 14(1):43-50, 2010
96.Hasegawa M, Kondo F, Yamamoto K, Murakami K, Tomita M, Nabeshima K, Nakai S, Kato M, Ohashi A, Arai J, Hiki Y, Ishii J, Emi N, Sugiyama S, Yuzawa Y., Evaluation of blood purification and bortezomib plus dexamethasone therapy for the treatment of acute renal failure due to myeloma cast nephropathy. Ther Apher Dial. 14(5):451-6, 2010
97.Mizuno T, Mizuno M, Morgan BP, Noda Y, Yamada K, Okada N, Yuzawa Y, Matsuo S, Ito Y., Specific collaboration between rat membrane complement regulators Crry and CD59 protects peritoneum from damage by autologous complement activation. Nephrol Dial Transplant. 26(6):1821-30, 2011
98.Sawai A, Ito Y, Mizuno M, Suzuki Y, Toda S, Ito I, Hattori R, Matsukawa Y, Gotoh M, Takei Y, Yuzawa Y, Matsuo S., Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients. Nephrol Dial Transplant.  26(7):2322-32. 2011
99.Kato N, Kosugi T, Sato W, Ishimoto T, Kojima H, Sato Y, Sakamoto K, Maruyama S, Yuzawa Y, Matsuo S, Kadomatsu K. Basigin/CD147 promotes renal fibrosis after unilateral ureteral obstruction. 178(2):572-9. Am J Pathol. 2011
100.Kato K, Kosugi T, Sato W, Arata-Kawai H, Ozaki T, Tsuboi N, Ito I, Tawada H, Yuzawa Y, Matsuo S, Kadomatsu K, Maruyama S. Growth factor Midkine is involved in the pathogenesis of renal injury induced by protein overload containing endotoxin. Clin Exp Nephrol. 15(3):346-54 2011
101.Tatsuhito Watanabe, Shoichi Maruyama, Tokunori Yamamoto, Izumi Kamo, Kaoru Yasuda1, Yosuke Saka, Takenori Ozaki, Yukio Yuzawa, Seiichi Matsuo, Momokazu Gotoh., Increased urethral resistance by periurethral injection of low serum cultured adipose-derived mesenchymal stromal cells in rats. International Journal of Urology. in print, 2011
102.Mizuno M, Ito Y, Tanaka A, Suzuki Y, Hiramatsu H, Watanabe M, Tsuruta Y, Matsuoka T, Ito I, Tamai H, Kasuga H, Shimizu H, Kurata H, Inaguma D, Hiramatsu T, Horie M, Naruse T, Maruyama S, Imai E, Yuzawa Y, Matsuo S., Peritonitis is still an important factor for withdrawal from peritoneal dialysis therapy in the Tokai area of Japan.  Clin Exp Nephrol. 2011 Jun 21. [Epub ahead of print]
103.Sugiyama H, Yokoyama H, Sato H, Saito T, Kohda Y, Nishi S, Tsuruya K, Kiyomoto H, Iida H, Sasaki T, Higuchi M, Hattori M, Oka K, Kagami S, Nagata M, Kawamura T, Honda M, Fukasawa Y, Fukatsu A, Morozumi K, Yoshikawa N, Yuzawa Y, Matsuo S, Kiyohara Y, Joh K, Taguchi T, Makino H; Committee for Standardization of Renal Pathological Diagnosis and Working Group for Renal Biopsy Database, Japanese Society of Nephrology, Tokyo, Japan., Japan Renal Biopsy Registry: the first nationwide, web-based, and prospective registry system of renal biopsies in Japan. Clin Exp Nephrol. 15(4):493-503, 2011
104.Watanabe T, Maruyama S, Yamamoto T, Kamo I, Yasuda K, Saka Y, Ozaki T, Yuzawa Y, Matsuo S, Gotoh M., Increased urethral resistance by periurethral injection of low serum cultured adipose-derived mesenchymal stromal cells in rats. Int J Urol. 18(9):659-66, 2011
105.Kanayama K, Ohashi A, Hasegawa M, Kondo F, Yamamoto Y, Sasaki M, Hayashi H, Kato M, Hattori R, Yamashita H, Arai J, Ishii J, Emi N, Yuzawa Y., Comparison of free light chain removal by four blood purification methods. Ther Apher Dial. 15(4):394-9, 2011
106.Yasuda K, Ozaki T, Saka Y, Yamamoto T, Gotoh M, Ito Y, Yuzawa Y, Matsuo S, Maruyama S.  Autologous cell therapy for cisplatin-induced acute kidney injury by using non-expanded adipose tissue-derived cells. Cytotherapy. 2(1):159-68, 2012
107.Kato S, Lindholm B, Stenvinkel P, Ekström TJ, Luttropp K, Yuzawa Y, Yasuda Y, Tsuruta Y, Maruyama S., DNA hypermethylation and inflammatory markers in incident Japanese dialysis patients.  Nephron Extra. 2(1):159-68, 2012
108.Takahashi R, Ito Y, Takahashi H, Ishii H, Kasuga H, Mizuno M, Suzuki Y, Yuzawa Y, Maruyama S, Murohara T, Imai E, Matsuo S., Combined values of serum albumin, C-reactive protein and body mass index at dialysis initiation accurately predicts long-term mortality.  Am J Nephrol. 36(2):136-43, 2012
109.Yamamoto J, Sato W, Kosugi T, Yamamoto T, Kimura T, Taniguchi S, Kojima H, Maruyama S, Imai E, Matsuo S, Yuzawa Y, Niki I. Distribution of hydrogen sulfide (H(2)S)-producing enzymes and the roles of the H(2)S donor sodium hydrosulfide in diabetic nephropathy.,  Clin Exp Nephrol., 2012 Aug 8. [Epub ahead of print]
110.Hasegawa M, Ishii J, Kitagawa F, Kanayama K, Takahashi H, Ozaki Y, Yuzawa Y., Prognostic value of highly sensitive troponin T on cardiac events in patients with chronic kidney disease not on dialysis. Heart Vessels.,  2012 Aug 23. [Epub ahead of print]
111.Yamamoto Y, Hiki Y, Nakai S, Yamamoto K, Takahashi K, Koide S, Murakami K, Tomita M, Hasegawa M, Kawashima S, Sugiyama S, Yuzawa Y., Comparison of effective impact among tonsillectomy alone, tonsillectomy combined with oral steroid and with steroid pulse therapy on long-term outcome of immunoglobulin A nephropathy. Clin Exp Nephrol.,  2012 Aug 29. [Epub ahead of print]
112.Hirayama A, Nakashima E, Sugimoto M, Akiyama S, Sato W, Maruyama S, Matsuo S, Tomita M, Yuzawa Y, Soga T., Metabolic profiling reveals new serum biomarkers for differentiating diabetic nephropathy., Anal Bioanal Chem. 404(10):3101-9, 2012
113.Takahashi H, Ishii H, Ito Y, Maruyama S, Murohara T, Yuzawa Y, Matsuo S., Association of Cardiac Valvular Calcifications and C-Reactive Protein With Cardiovascular Mortality in Incident Hemodialysis Patients: A Japanese Cohort Study. Am J Kidney Dis., 2012 Nov 1. [Epub ahead of print]

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